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Medical Devices ~ Microfabrication of Biosensors ~ Molecular Biology

         Molecular biology expertise spans cell culture (endothelial, vascular smooth muscle, bone, and embryonic stem cells) mRNA purification and RT-PCR, gel electrophoresis for Western Blot, siRNA and gene silencing.

         Savvy in fluorescence microscopy, flow cytometry, bioassays for detection of free radical species, using spectrophotometers, ELISA, cytotoxicity assay, bio compatibility testing, and design of lateral flow devices.

         Excel at planning, design, fabrication, and testing of biosensors, catheter-based shear stress sensor, pressure sensor, and temperature sensor.

         Adept at photolithography, wet etching, scanning electron microscopy sputtering, e-beam metal deposition, and design and fabrication of PDMS microfluidics channels.

         Advanced knowledge of medical device regulations, quality systems and standards (ISO 9001 / ISO 13485), biocompatibility standards (ISO 10933), IRB, 510K and PMA submissions, and cGMP and GLP guidelines.

         Outstanding ability to understand and communicate scientific information, work in cross-disciplinary teams, and balance concurrent project tasks in alignment with schedules and budgets.

         Skilled at designing experiments, ensuring rigorous regulatory compliance, administering quality control to ensure accuracy of data, and maintaining state-of-the-art lab instruments and equipment.

Physical Optics Corporation, Torrance, CA, 2015 to Present

Research Scientist & Principal Investigator

         Spearhead broad-scope SBIR-funded research projects, demonstrating exceptional organizational, analytical, and documentation skills.

Pharmaco-kinesis Corporation, Los Angeles, CA, 2013 to 2015

Consultant and Technical Writer

         Provided high-level consultative guidance regarding biosensor technology research and development, and authored associated technical documentation.

         Secured $150K Phase I award from DoD for "Nano-Impedance biosensor for early detection of organ injury".

University of California, Irvine, 2013 & 2014

Instructor, Biomedical Engineering

         Taught Design of Biomedical Electronics and Introduction to Biomedical Engineering to undergraduates.

Walve, Corp., 2012 to 2013

Consultant and Technical Writer

         Documented development of cutting-edge device attached to a heart valve or annuloplasty ring.

         Created and maintained comprehensive databases to store and track influential research data.

Physical Optics Corporation, Torrance, CA, 2009 to 2010

Research Scientist

         Executed SBIR government-funded projects such as 3D Microfluidic Platform for in vitro Hematopoietic Stem Cell Culture; Regenerative Enzymatic Biofuel Cell in a Multi-Array Microfluidic Configuration; Leptospirosis Detection Dipstick; Dielectrophoretic Microfluidic Protein Analysis System; and Combined Dielectrophoretic Microfluidic System.

         Generated informative, detailed, and compelling proposals in response to solicitations from government agencies including NIH and Department of Defense.

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University of Southern California, Los Angeles, CA, 2001 to 2008

Post-doctorate Research Associate, Cardiovascular Engineering Laboratory 2007 to 2008

         Methodically investigated and documented mitochondrial membrane potential and oxidative stress in mouse and human embryonic stem cells under pulsatile shear stress.

         Orchestrated study of polymer flexible MEMS shear stress sensor for intravascular shear stress monitoring in vivo in White New Zealand rabbit.

Graduate Student Researcher & AHA Pre-Doctoral Fellow, Cardiovascular Engineering Lab 2003 to 2007

         Critically analyzed spatial variations in shear stress that regulated vascular oxidative stress.

         Resourcefully leveraged ln203 nanowires for accurate detection of oxidized low-density lipoprotein.

         Successfully created miniaturize enzyme-based biofuel cells and glucose sensors.

         Tested and recorded effect of treatment with 178- Estradiol on free radical species production.

         Systemically researched catheter-based MEMS shear stress sensor for design, fabrication, and testing.

Graduate Student Researcher, Computer Architecture Lab 2001 to 2002

         In collaboration with Department of Electrical Engineering at IBM TJ Watson Research Center, investigated memory performance and conducted trace-driven evaluation for cache design.

Institute d Electronique Fundamental, University of Paris, France, 2000

Graduate Student Researcher

         Contributed to planning and design of asynchronous 1024-bit coprocessor to be integrated within RSA encryption/decryption applications using parallel architecture.

Additional experience includes role as Teaching Assistant, Electrical Engineering,

University of Southern California, 2002 & 2003 (summers).

Ph.D., Biomedical Engineering, University of Southern California, 2007

Master of Science, Medical Devices and Diagnosis Engineering, University of Southern California, 2006

Master of Science, Electrical Engineering, University of Southern California, 2002

D.E.A, Electrical Systems for Signal Processing, University of Paris 11, France, 2000

Bachelor of Science, Electrical Engineering/Electronics, Sharif University of Technology, Tehran, Iran, 1999

Academic Honors and Awards:

2-time Winner of Women in Science and Engineering Travel Award (AHA & FASEB) 2007

APSIH Award of Academic Excellence 2007

Grodins Outstanding Poster Presentation 2007

American Heart Association (AHA) Pre-Doctoral Fellowship 2006-2007

Alfred Mann Institute Fellowship 2004-2006

Grodins Graduate Oral Presentation Award 2004

Graduate of (NODET) National Organization for Development of Exceptional Talent 1999

IEEE, EMBS member

American Heart Association, Atherosclerosis, Thrombosis and Vascular Biology

Biomedical Engineering Society

American Association for the Advancement of Science (AAAS)

MATLAB, SimuLink, LabView, C++, AutoCAD, Microsoft Office Suite (PowerPoint, Excel, Word, Outlook),

Fluent, Gambit, SolidWorks, PowerView, Magic, PSpice

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Refereed Journal Publications

Rongsong Li, Tyler Beebe, Jeff Cui, Mahsa Rouhanizadeh, Lisong Ai, Pin Wang, Martin Gundersen, Wakako Takabe, Tzung Hsiai, Pulsatile Shear Stress Increased Mitochondrial Membrane Potential : Implication of Mn-SOD, Biochem Biophys Res Commun, October 16, 2009, 388(2): 406 412.

Hongyu Yu, Lisong Ai, Mahsa Rouhanizadeh, Darshin Patel, Eun Sok Kim, Tzung Hsiai, Flexible Polymer Sensors for in vivo Intravascular Shear Stress Analysis, IEEE/ASME Journal of Microelectromechanical Systems, 2008,Volume: 17 , Issue: 5, Page(s): 1178 - 1186.

Lisong Ai*, Mahsa Rouhanizadeh*, Joseph C Wu, Wakako Takabe, Hongyu Yu, Mohammad Alavi, Rongsong Li, Yi Chu, Jordan D Miller, Donald D. Heistad, and Tzung Hsiai. Shear Stress Influences Spatial Variations in Vascular Mn-SOD Expression: Implication for LDL Nitration Am J Physiol Cell Physiol (April 23, 2008).

Tzung K Hsiai, Juliana Hwang, Mark L Barr, Adrea Correa, Ryan Hamilton, Mohammad Alavi, Mahsa Rouhanizadeh, Enrique Cadenas, Stanley L Hazen. Hemodynamics Influences Vascular Peroxynitrite Formation: Implication for LDL Apo B-100 Nitration, Free Radical Biology & Medicine, 2007 Feb 15;42(4):519-529.

Lucas Demaio, Mahsa Rouhanizadeh, Srinivasa Reddy, Juliana Hwang, Tzung Hsiai. Oxidized Phospholipids Mediate Occludin Expression and Phosphorylation in Vascular Endothelial Cells, Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H674-83.

Tao Tang, Xiaolei Liu, Chao Li, Bo Lei, Daihua Zhang, Mahsa Rouhanizadeh, Tzung Hsiai, and Chongwu Zhou. Complementary Response of In2O3 Nanowires and Carbon Nanotubes to Low-Density Lipoprotein Chemical Gating, Applied Physics Letter 86, 103903 (2005).

Li, C., Lei, B., Tang, T., Zhang, D., Rouhanizadeh, M., Hsiai, T., and Zhou, C. Chemical Gating of In2O3 Nanowires by Organic and Biomolecules, Applied Physics Letter, 2003, Vol. 83(19), 2003: 014-6.

Juliana Hwang*, Mahsa Rouhanizadeh*, Howard Hodis, Tzung Hsiai. 17β- Estradiol Modulates Oscillatory Shear Stress Mediated Endothelial Superoxide Production: Implication for LDL Oxidation, Free Radical Biology & Medicine, 2006 Aug 15; 41(4):568-78

Mahsa Rouhanizadeh, Juliana Hwang, Roza Clempus, Laura Marcu, Bernard Lassegue, Tzung Hsiai. Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine Induced Vascular Endothelial Superoxide Production: Implication of NADPH Oxidase, Free Radical Biology & Medicine, 2005 Dec 1; 39(11):1512-22.

Mahsa Rouhanizadeh, Tiantian Lin, Diego Arcas, Juliana Hwang, Tzung Hsiai Spatial variations in shear stress in a 3-D bifurcation Model at Low Reynolds numbers Annals of Biomedical Engineering, Vol. 33, No. 10, October 2005, pp. 1425-1440.

Mahsa Rouhanizadeh, Tao Tang, Chao Li, Juliana Hwang, Chongwu Zhou, Tzung Hsiai Differentiation of oxidized low density lipoproteins by nanosensors Sensors and Actuators B, Volume 114, issue 2, April 2006, Pages 788-798.

Mahsa Rouhanizadeh, Gopikrishnan Soundararajan, Ronalee Lo,Diego Arcas, Frederick Browand, Tzung K. Hsiai MEMS sensors to resolve spatial variations in shear stress in a 3-D blood vessel bifurcation model IEEE sensor Journal ,Volume 6, No.1, February 2006, Pages 78-88.

Soundararajan, G., Rouhanizadeh, M., Yu, H. Kim, E. S., Hsiai, T., Micro-sensors to characterize shear stress in a microfluidic channel , Sensors and Actuators A, Volume 118, Issue 1 , 31 January 2005, Pages 25-32.

Book Chapters

Hongyu Yu, Mahsa Rouhanizadeh, Lisong Ai, Tzung K. Hsiai, Heterogeneous Nano Structures: Multiscale structures with NEMS and MEMS components , to appear in Bio-inspired and Nano-scale Integrated Computing, Wiley Press, 2007

Mahsa Rouhanizadeh*, Hongyu Yu*, Lisong Ai, Jennifer Xu, Tzung K. Hsiai, Micro- and Nano-Scale Anemometry: Implication for Biomedical Applications to appear in Encyclopedia of Micro- and Nano-Fluidics, Springer (*both authors contribute equally)

Mahsa Rouhanizadeh, Wakako Takabe, Lisong Ai, Hongyu Yu, Tzung Hsiai, Monitoring Oxidative Stress in Vascular Endothelial Cells in Response to Fluid Shear Stress: From Biochemical Analyses to Micro- and Nano-Technologies in Methods in Enzymology MIE Volume 441 (Nitric Oxide Part G), (Submitted)

Patent

Tzung Hsiai, Gopikrishnan Soundararajan, E.S. Kim, Hongyu yu, Mahsa Rouhanizadeh, Christina Tiantian Lin, MEMS Vascular sensor , US Patent No. 8,216,434 , Application No. 12/041,577

Grants

Integrated Blood Analyzer for Austere Environment; agency: DOD/SOCOM, Principal Investigator (achieved Phase I award of $150K)

Paper-based Integrated Microfluidic Hematology Analyzer; agency: DOD/DHP-ARMY, Principal Investigator (achieved Phase I award of $150K)

3D Microfluidic Platform for in vitro Hematopoietic Stem Cell (HSC) Culture; agency: DOD/CBD/DTRA, Principal Investigator (achieved Phase I award of $70K)

Regenerative Enzymatic Biofuel Cell in a Multi-Array Microfluidic Configuration; agency: DOD/OSD, Principal Investigator (achieved Phase I award of $100K)

Nano-therapeutic for Peripheral Neuropathy; agency: DOD/DHP-ARMY, Phase II Project Manager ($750k)

Leptospirosis Detection Dipstick; agency: Army, Project Manager

Dielectrophoretic Microfluidic Protein Analysis System; agency: Army, Project Manager (achieved Phase II award of $750K)

Combined Dielectrophoretic Microfluidic System; agency: Army, Project Manager

Peer-Reviewed Conference Proceedings

Mahsa Rouhanizadeh, Tzung Hsiai, Localization and detection of oxidized LDL by MEMS shear stress sensors and In2O3 nanowire/carbon nanotube based FETs , 33th Annual FACSS Meeting, Lake Beuna vista, Florida, September 2006 ( Invited talk)

Rouhanizadeh, M., Hamilton R., Cadenas E., Hsiai TK., Regulation of Mitochondria membrane Potential by Shear Stress: Implication of .NO Signaling , AHA scientific sessions 2007, Orlando Florida, November 2007.

Hongyu Yu, Lisong Ai, Mahsa Rouhanizadeh, Ryan Hamilton, Julian Hwang, ES Kim, Tzung Hsiai, FLEXIBLE CATHETER-BASED CARDIOVASCULAR SHEAR STRESS SENSORS , BMES 2007, Los Angeles.

Rouhanizadeh, M, Hamilton R. Cadenas E., Hsiai TK, Pulsatile Shear Stress Regulates Mitochondrial Membrane Potential , BMES 2007, Los Angles.

Hsiai, T., Rouhanizadeh, M., Barr, M., Correa, A., Alavi, M., Cadenas, E., Hwang, J., Hazen, S. L., Oscillatory shear stress promotes nitrative stress relative to pulsatile shear stress: A potential mechanism for athero-prone regions within vascular bifurcations . IEEE EMBS, New York City, August 2006.

Rouhanizadeh, M., Hsiai, T. Flow regulation of vascular Mn SOD . AHA Atherosclerosis, Thrombosis, and Vascular Biology Meeting, Denver, Colorado, April 2006

DeMaio, L, Rouhanizadeh, M, Reddy, S., Hwang, J., Tzung Hsiai, Oxidized phospholipids mediate occluding expression and phosphorylation in vascular endothelial cells , Baltimore, BMES-2005

Tiantian Lin, Mahsa Rouhanizadeh, Juliana Hwang, Tzung Hsiai, Oscillatory shear stress promotes reactive oxygen and reactive nitrogen species relative to pulsatile flow: A potential mechanism for atherosclerotic prone regions within vascular bifurcations . International conference on Bio-nano-informatics Fusion, Los Angeles, 2005.

Mahsa Rouhanizadeh, Christina Lin, Juliana Hwang, Tzung Hsiai, 17-estradiol attenuates oscillatory shear stress-induced LDL oxidation , International conference on Bio-nano-informatics Fusion, Los Angeles, 2005.

Mahsa Rouhanizadeh, Tiantian C. Lin, Jordan D. Miller, Donald Heistad, Tzung K. Hsiai, Induction of BMP4 in Vascular Smooth Muscle Cells by Shear Stress , FASEB Experimental Biology Meeting , San Francisco, April 1-4 2006.

Mahsa Rouhanizadeh, Tiantian Lin, Yi Chu, Donald Heistad, Tzung K. Hsiai, Spatial variations regulation of expression of CuZn-SOD and Mn-SOD by shear stress in vascular tissue , FASEB Experimental Biology Meeting , San Francisco, April 1-4 2006.

Mahsa Rouhanizadeh, Tao Tang, Chao Li, Chongwu Zhou, Tzung Hsiai, Detection of Oxidized Low Density Lipoproteins by Indium Oxide Nanowires-Based Field Effect Transistor 26th IEEE-EMBS conference, San Francisco , September 1-5 2004.

Rouhanizadeh, Mahsa, Tao Tang, Chao Li, Gopikrishnan Soundararajan, Chongwu Zhou, and Tzung K. Hsiai Applying Indium Oxide Nanowires as Sensitive and Specific Redox Protein Sensors , 11th Forsight Conference, San Francisco 2003

Tao Tang, Xiaolei Liu, Chao Li, Bo Lei, Daihua Zhang, Mahsa Rouhanizadeh, Tzung Hsiai, and Chongwu Zhou, Nanomaterials as Low Density Lipoprotein (LDL) Sensors A5.26, MRS Proceeding Volume 828, symposium B, San Francisco 2004.

Rouhanizadeh M., Tang, T., Li, C., Soundararajan, G., Zhou, C., Hsiai, T. Applying Indium Oxide Nanowire as Sensitive and Selective Redox Protein Sensors , Proceedings, 17th IEEE International Conference on Micro Electro Mechanical Systems MEMS 2004, Vol. 1: 431-4.

M. Dubois, J. Jeong, S. Jahromi, M. Rouhanizadeh, and A. Nanda, "Evaluation of Shared Cache Architectures for TPC-H.," 5th Workshop on Computer Architecture Evaluation using Commercial Workloads, Cambridge, Mass., Feb 2002, pp. 5-12.

Institutional Research Protocols:

IACUC: Nano-Therapeutics for Peripheral Neuropathy , Los Angeles Biomedical Research Institute.