Hardworking, dynamic professional with 10 years of progressive research neuroscience and related experience, paired with two PhD degrees rooted in theoretical physics and biomedical sciences. Also holds 15 years of experience as it related to object-oriented programming. Adept in developing image analysis and signal processing software. Skilled in the development and execution of MRI and EEG data analysis and programming, along with novel algorithms in computer vision, machine learning, signal processing and non-linear optimization. Possesses vast subject matter expertise specific to knowledge-based engineering domain image features used to improve machine learning algorithms that fuel increased biomedical image understanding. Authored over 20 peer-reviewed publications and two funded postdoctoral fellowship grants.

Presently targeting Scientist, Senior Engineer or related roles in industrial, governmental or educational work environments that will allow for continued leverage of medical image processes, software development, segmentation and machine learning skills and abilities; also open to position that focus on computer vision, machine learning algorithm development or data analysis.

Computer Programming Software Development Machine Learning Optimization Signal Processing Data Analysis Computer Simulation Protein Structure Modeling Molecular Dynamics Simulation Computational Nuclear Physics

Electrophysiology Molecular Biology Cell Biology Biomaging Histology Critical Thinking Leadership Skills

Cross-Functional Teamwork Strategic Planning Process Improvement Problem Solving Relationship Building Interpersonal Communication Matlab Java C++ MySQL Fortran Unix PC Mac

         Fulfill daily duties and responsibilities; facilitate assessments and perform analyses within the Institute s Brain Imaging and EEG Lab

         Complete structural and functional MRI image processing and statistical data analysis; continuously devise and implement innovative and effective analysis methods

         Fuel the delivery of machine learning-based image segmentation algorithms

         Developed an original statistical analysis algorithm that allowed for the mapping of statistical parametrics mapping (SPM) and used brain images of multiple modalities in voxel-wise statistical analysis

         Created a MATLAB graphical interface (GUI) for statistical analyses; allows users to lead highly-customized data analysis pipelines without the need for editing programs; also developed an SPM extension GUI to add additional software features

         Served in various capacities prior to employment with the Northern California Institute of Research and Education

         Directed image analysis and signal processing efforts

         Developed software that automated the single-molecule fluorescence microscopy video quality control process; also allowed for sound object detection, shape classification, tracking, as well as signal quantification and statistical analysis

         Developed computer vision algorithms and signal processing; included edge detection, image segmentation, object recognition/tracking, signal step detection/noise reduction and non-linear optimization

         Efficaciously completed a 3D image reconstruction of the brain regions in mice subjects

         Determined the electrophysiological properties of neural stem cells with precision and accuracy

         Gained noted proficiency in ion channel function and regulation

Extension GUI of statistical parametric mapping (SPM) software that interacts with SPM to extend functionality; includes image manipulations and interactive data plotting elements

Sophisticated image analysis and signal processing software that automates single-molecule fluorescence microscopy video quality control, as well as object detection, shape classification and tracking. Also allowed for signal quantification and statistical analysis with a source code of over 140K lines independent of incorporated third party source codes

Software for analyzing electrophysiology data including advanced single-channel analysis; developed to perform advanced single-channel analysis that is difficult/impossible to perform using commercially available software

Identified a position in a multiple sequence alignment of closely related proteins. Contained certain physical-chemical properties of residues that highly correlate with functional differences

Crafted a utility program that designs silent mutations and creates unique restriction sites within ranges in a cDNA sequence

Computed energy levels and wave functions of the yrast state and low-lying excited states of well-deformed rare earth nuclei

Ph.D., Biomedical Sciences, New York University Mount Sinai School of Medicine

Ph.D., Physics, Peking University

B.S., Physics, Jilin University

Award for Academic Excellence, New York University Mount Sinai School of Medicine

Postdoctoral Fellowship Award, American Heart Association, 2006 2008

Revson Fellowship in Biomedical Sciences, 2003 2005

         Yaping Sun, Zhiqiang Dong, Yyyyyy x. yyyyyy, Kenny Kean-Hooi Ang, Miller Huang, Kelly M. Haston, Jisong Peng, Tao Zhong, Steven Finkbeiner, William Weiss, Michelle Arkin, Lily Y. Jan, and Su Guo (2013) "Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells", (eLife, 2013;2:e00508).

         Huanghe Yang, Andrew Kim, Daniel Palmer, Yyyyyy x. yyyyyy, Jason Tien, Fen Huang, Tong Cheng, Shaun Coughlin, Yuh Nung Jan & Lily Yeh Jan, (2012). "TMEM16F encodes a novel Ca²⁺-activted cation channel important for Ca²⁺-dependent lipid scrambling", Cell, 151: 111-122

         Styer, A.M., Mirshahi, U.L., Wang, C., Girard, L., Jin, T., Logothetis, D.E., and Mirshahi,T. (2010). "G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels", J. Biol. Chem. 285: 41290-41299.

         Yyyyyy x. yyyyyy, Jin Liang Sui, Avia Rosenhouse-Dantsker, Kim W. Chan, Lily Y. Jan and Diomedes E. Logothetis (2008) "Stoichiometry of Kir channels with phosphatidylinositol bisphosphate", Channels 2: 1- 15.

         deHart,G.W., Jin,T., McCloskey,D.E., Pegg,A.E., and Sheppard,D. (2008). "The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel", Proc. Natl. Acad. Sci. U. S. A. 105: 7188-7193.

         Logothetis,D.E., Jin,T., Lupyan,D., and Rosenhouse-Dantsker,A. (2007). "Phosphoinositide-mediated gating of inwardly rectifying K⁺ channels", Pflugers Arch. 455: 83-95.

         Mirshahi T, Jin T, Logothetis DE. (2003) "G beta gamma and KACh: old story, new insights", Sci STKE. 2003 Aug 5 (194):PE32.

         Hailin Zhang, Liviu C. Craciun, Tooraj Mirshahi, Tibor Roh cs, Coeli M. B. Lopes, Yyyyyy x. yyyyyy and Diomedes E. Logothetis (2003). "PIP₂ activates KCNQ channels and its hydrolysis underlies receptor-mediated inhibition of M currents", Neuron 37: 963-975.

         Rohacs,T., Lopes,C.M., Jin,T., Ramdya,P.P., Molnar,Z., and Logothetis,D.E. (2003). "Specificity of activation by phosphoinositides determines lipid regulation of Kir channels", Proc. Natl. Acad. Sci. U.S.A 100: 745-750.

         Jin,T., Peng,L., Mirshahi,T., Rohacs,T., Chan,K.W., Sanchez,R., and Logothetis,D.E. (2002). "The betagamma Subunits of G Proteins Gate a K(+) Channel by Pivoted Bending of a Transmembrane Segment." Mol Cell 10, 469-481.

         Lopes,C.M., Zhang,H., Rohacs,T., Jin,T., Yang,J., and Logothetis,D.E. (2002). "Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies" Neuron 34: 933-944.

         He, C., Yan, X., Zhang, H., Mirshahi, T., Jin, T., Huang, A., and Logothetis, D.E. (2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K⁺ channel activity through interactions with the beta gamma subunits of G proteins", J. Biol. Chem. 277: 6088-6096.

         Kobrinsky,E., Mirshahi,T., Zhang,H., Jin,T., and Logothetis,D.E. (2000). "Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K⁺-current desensitization", Nature Cell Biology 2: 507-514.

         Goodman, A.L. and Jin, T. (1997) "Second shape transition temperature: prolate noncollecctive to oblate noncollective", Z. Phys. A 358: 131-132.

         Goodman, A.L. and Jin, T. (1996) "Systematics of first and second shape transition temperatures in heavy nuclei", Phys Rev. C54: 1165-1168.

         Goodman, A.L. and Jin, T. (1996) "Temperature induced shape transition: prolate noncollective to oblate noncollective" Nuclear Physics A 611: 139-162.

         Zeng, J.Y., Jin, T., and Zhao, Z.J. (1994) "Reduction of nuclear moment of inertia due to paring interaction", Phys. Rev. C50: 746-756.

         Zeng, J.Y., Lei, Y.A., Jin, T., and Zhao, Z.J. (1994) "Blocking effect and odd-even differences in the moments of inertia of rare-earth nuclei", Phys. Rev. C50: 1388-1397.

         Jin, T., Zhao, Z., Zeng, J. (1993) "Particle-number conserving calculation of the bandhead moments of inertia of identical SD bands", High Energy and Nuclear Physics 18 (3): 239-248.

         Jin, T., Zhao, Z., Zeng, J. (1993) "Blocking effects and underlying physics of identical bands of normally deformed nuclei at low spin", Science in China (Series A) 37 (7): 823-829.

         Zhao, Z. and Jin, T., (1992) "Microscopic mechanism of the variation of the ground band moments of inertia with neutron number in ^166-176Yb", High Energy and Nuclear Physics 16: 754.

        Rohacs T., Lopes C., Mirshahi T., Jin T., Zhang H. and Logthetis D.E. (2002) "Assaying PIP₂ regulation of Potassium Channels", Methods Enzymol 345:71-92 Ed: Hildebrandt and Iyengar.

• Huanghe Yang, Andrew Kim, Tovo David, Daniel Palmer, Yyyyyy x. yyyyyy, Jason Tien, Fen Huang, Tong Cheng, Shaun Coughlin, Yuh Nung Jan, Lily Y. Jan (2013) "Tmem16F forms a Ca²⁺-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation", Biophysical Journal 104(2) pp. 366a
• Huanghe Yang, Yyyyyy x. yyyyyy, Tong Cheng,  Yuh Nung Jan, Lily Yeh Jan (2011) "Scan: A Novel Small-Conductance Ca2+-Activated Non-Selective Cation Channel Encoded by TMEM16F" BIOPHYSICAL JOURNAL  Volume: 100   Issue: 3   Supplement: 1   Pages: 259-259
• Yyyyyy x. yyyyyy, Bensheng Liu, Luying Peng, Diomedes E. Logothetis, Yuh Nung Jan, Lily Y. Jan (2008) "Different Roles Attributed To The Hydrophobicity And The Aromaticity Of The Phenylalanine Residue Located At The Helix Bundle Crossing Region Of Girk Channels", Biophys. J. Supplement 191, Abstract, 938-Plat

• Yyyyyy x. yyyyyy, Bensheng Liu, Luying Peng, Diomedes Logothetis, Yuh Nung Jan, Lily Yeh Jan (2007) "Exploration of the structural basis for GIRK channel gating via unbiased yeast screens and single channel analyses", Biophys. J. Supplement 104a, Abstract, 484-Pos
• Yyyyyy x. yyyyyy, Bensheng Liu, Radda Rusinova, Matthew Hopperstad, Diomedes Logothetis. (2006) "Single Channel Studies of Regulation of G Protein-Sensitive K⁺ (GIRK) Channel Activity by PIP2: Interaction Kinetics, Stoichiometry and Stabilization by Gbg, Biophys. J. Supplement, Abstract, 837-Plat
• Jin TH, Hopperstad M, Logothetis D (2005) "Single Channel Studies of Regulation of G Protein-Sensitive K⁺ Channel Activity by PIP₂: Interaction Kinetics, Stoichiometry and Stabilization by Gbg, FESAB Summer Research Conference, Snowmass, CO June 2005.
• Jin TH, Hopperstad M, Logothetis D (2005) "Distinct time scales at which PIP2 and G beta gamma interact with inwardly rectifying G protein activated K+ (GIRK) channels", Biophys. J. 88 (1): 103A-104A
• Yyyyyy x. yyyyyy, Matthew Hopperstad and Diomedes Logothetis (2004) "Distinct time scales at which PIP2 and G beta gamma interact with inwardly rectifying G protein activated K+ (GIRK) channels", 58^th Annual Meeting and Symposium of the Society of General Physiologists, Woods Hole, MA Sept. 2004.
• Jin TH, Logothetis DE (2004) "Effects of altered channel-PIP2 interactions on single-channel kinetics of inwardly rectifying K+ (Kir) channels", Biophys. J 86 (1): 439A-440A
• Yyyyyy x. yyyyyy, Tibor Rohacs, Diomedes Logothetis (2003) "Identification of functionally important candidate residues in protein families", Biophys. J. 84, 79a.
• Tibor Rohacs, Coeli MB Lopes, Yyyyyy x. yyyyyy, Pavan P Ramdya, Diomedes E Logothetis (2003) "Acyl-CoA Activation of Kir Channels Depends on Low Specificity of Activation by Phosphoinositides", Biophys. J. 84, 227a.
• Avia Rosenhouse-Dantsker, Yyyyyy x. yyyyyy, Diomedes E. Logothetis (2003) "Proline mutations in the TM2 helix of GIRK4* enhance channel activity via two different mechanisms", Biophys. J. 84, 79a.
• Jin,T., Roberto Sanchez, and Diomedes Logothetis (2002). "Identification of the gate of GIRK channels regulated by the bg subunits of G proteins", Biophys. J. 82, 591a.
• Tibor Rohacs, Coeli Lopes, Yyyyyy x. yyyyyy, and Diomedes Logothetis (2002). "C and N terminal determinants of the specificity of interaction of inwardly rectifying K+ channels with PIP2", Biophy. J. 82, 181a.
• Xixin Yan, Cheng He, Hailin Zhang, Yyyyyy x. yyyyyy, Tooraj Mirshahi, and Diomedes E Logothetis (2001). "N- and C-terminal residues of GIRK4 critical for channel activation by the bg subunits of G protein", Biophys. J. 80, 623a.
• Jin,T. and Logothetis,D. (2000). "Alterations in GIRK Channel Interactions with PIP2 Affect Single-Channel Kinetics", Biophys. J. 78, 346A.
• Jin, T. H., Colson, A., and Osman, R. (1998). "Docking of TRH to the receptor in the presence of water", Biophys. J. 74, A88.
• Zhao Zhengji, Jin Taihao and Zeng Jinyan (1994). "Reliability of the Truncation in Accordance with the Interaction Matrix Elements", The fifth Chinese National Conference on Nuclear Physics (Oct. 6-12, 1994, Yichang, Hubei, China).
• J. Y. Zeng, T. H. Jin, Z. J. Zhao, and C. S. Wu (1993). "Blocking effects and underlying physics of identical bands of normally deformed nuclei at low spin", Proceeding of International Symposium on Latest Topics in Nuclear Structure (Oct. 25-28, 1993, Beijing, China) p. 18.