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Quality Control & Assurance Regulatory Compliance Lab Operations
Research & Data Analysis Medical Devices Data-Driven Decision-Making
Strong background in molecular biology, tissue engineering, in vivo rodent studies, and pre-clinical drug testing; outstanding ability to understand and communicate scientific information, work in cross-disciplinary teams, and balance concurrent project tasks in alignment with schedules and budgets.
Extensive lab research expertise spanning animal model testing, immunofluorescence, serum biochemistry, collagen fractionation, genotyping, endocytosis, chemotaxis, tissue culture, buffer and reagent preparation, fabrication techniques, gel electrophoresis, PCR screening, and RT-PCR.
Well-versed in nano-biotechnology, biomedical engineering, biochemistry, bioinformatics, biomaterials and implants, biomechanics, rehabilitation engineering, and life sciences.
Skilled at designing experiments, ensuring stringent regulatory compliance, administering quality control to ensure accuracy of data, and maintaining sophisticated lab instruments and equipment.
Meticulously document procedures, calculations, measurements, observations, and analysis of results.
Possess exceptional critical thinking, analytical, problem solving, communication, and multi-tasking skills.
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 2015 to Present
Research Assistant II
Independently direct full-scope lab operations including staff hiring and training, administrative functions, safety compliance, team collaboration, and records maintenance.
Proficiently leverage in vivo techniques such Oral Gavage, IP injection, subcutaneous administration of analgesics, and non-survival surgery for collecting blood (cardiac puncture) and liver tissue.
Perform breeding and genotyping of mouse colony in different strains and methodically set up experiments for pre-clinical drug trials.
Measure collagen content in liver tissue using biochemical assays and document findings.
Successfully established working protocol of double immunofluorescence for integrin avb6/pCK markers to quantify rate of proliferation in hepatic progenitor cell (HPC) function and promotion of ductular reaction (DR), fibrosis, and tumorigenesis.
Lawrence Bonassar Lab, Cornell University, Ithaca, 2013 to 2014
Independently explored current culture system for producing tissue engineered menisci and re-engineered scaled-down version to yield better quantitative results.
Championed experiment using 3D scaffold tissue engineering protocol and principles of mammalian cell/ tissue culture to study mechanical contraction properties of construct under different experimental conditions.
Collected sectional samples from final product to perform comprehensive image analysis and compared results for change in fiber contraction properties when using stainless steel v/s SS+ brass clamps.
Mentored, trained, guided, supported, and motivated undergraduate student on experimental conditions and laboratory functions.
Kahini Vaid, MEng Page 2 of 2
Molecular Engineering Laboratory, Cornell University, Ithaca, 2013 to 2014
Achieved label-free detection of Bovine Serum Albumin (BSA) using SPR technique by immobilizing BSA in a microchip, adding anti- BSA antibody, and critically analyzing data using CLAMP software.
Administered ELISA assay to study presence of antibodies against small pox and anthrax antigens in the serum of four soldiers.
Isolated human DNA and compared DNA polymorphism between individuals via PCR amplification, gel electrophoresis and DNA sequencing using Sanger Sequencing technique.
Zydus Cadila Healthcare Pvt. Ltd., Ahmedabad, India, 2012
Quality Control Analyst Intern
Monitored and ensured rigorous quality control of pharmaceutical products by supporting broad-based operations across Aerosol, Microbiology, Stability, Raw Materials, and Finished Product departments.
Executed complex assays encompassing microbial limit test, endotoxin test, UODD test, cascade impactor test, and culture activity to assess quality performance.
Extensively worked with products throughout life cycle from sample collection and preliminary tests, to final submission and stringent compliance with cGMP and SOP guidelines.
Blind People s Association, Ahmedabad, India, 2012 to 2013
Fabricated prototype of a walking cane featuring ultrasonic sensor and a GPS-GSM module for obstacle detection and navigation to aid the blind and visually-impaired.
Indian Medical Device Industry Conference, Ahmedabad, India, 2011 to 2012
Coordinated global conference to facilitate influential discussions on healthcare and medical devices.
HCG Medisurge Hospitals Pvt. Ltd., Ahmedabad, India, 2011
Biomedical Engineer Intern
Shadowed surgeons during cancerous tumor removal, and gained considerable familiarity with medical instruments such as pulse oximeter, dialyzer, ECG- EMG machine, X-Ray machine, and defibrillator.
MEng, Biomedical Engineering, Cornell University, 2014
BEng, Biomedical Engineering, L.D College of Engineering, India, 2013
SolidWorks, MATLAB, Photoshop, GraphPad Prism 5, R programming, Microsoft Office (Word, Excel), CLAMP, HPLC, gas chromatography, mass spectrophotometer, dilution system, UV spectroscopy, Malvern Mastersizer
Peng, Z.-W., Ikenaga, N., Liu, S. B., Sverdlov, D. Y., Vaid, K. A., Dixit, R., Weinreb, P. H., Violette, S., Sheppard, D., Schuppan, D. and Popov, Y. (2016), Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis. Hepatology, 63: 217 232. doi:10.1002/hep.28274
Ikenaga, Naoki, et al. Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal. Gut, vol. 66, no. 9, Oct. 2017, pp. 1697 1708., doi:10.1136/gutjnl-2016-312473. Accessed 10 Jan. 2017.
Peng, Z., Rothweiler, S., Wei, G., Ikenaga, N., Liu, S. B., Sverdlov, D. Y., Vaid K.A., Popov, Y. V. (2017). The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis. Hepatology Communications. doi:10.1002/hep4.1084
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