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Project Management ~ Analytical Method Development

Team Leadership ~ Chemical Analysis ~ Product Development ~ GLP

         Highly accomplished Plant Physiologist with outstanding track record in agricultural biotechnology and crop protection.

         Exceptional talents across biochemical, phytochemical, agronomic, and molecular sciences.

         Equally effective in a leadership or collaborative role; extremely flexible depending on environment, project needs, and challenges.

         Excel at investigating organisms which affect fruit aging, and determining optimal chemical treatment to extend freshness of produce.

         Adept at managing technical project design, guiding appropriate patent action, calculating budget needs, controlling expenses, determining production methods for new products, and progress reporting.

         Advanced knowledge of chemical composition and processes of living organisms, excel at developing innovative analytical methods, and extremely well-versed in fruit maturity indices.

         Significant skills in conducting qualitative and quantitative chemical analyses.

DuPont Pioneer, Johnston, IA, 2016 to Present

DuPont Pioneer, Wilmington, DE, 2015 to 2016

Senior Research Manager

         Serve as integral member of Regulatory Science leadership team and Test Facility Management group.

         Plan, coordinate, and delegate tasks to Biochemical Analysis group, proficiently defining research goals and guiding staff in research strategies and approaches.

         Leverage advanced expertise in analytical biochemistry, plant biochemistry, and plant physiology to conduct analytical assays for special studies and author influential reports for regulatory agencies.

         Join forces with and supervise contract analytical laboratories in analyzing nutrient composition of transgenic crops.

         Co-chair of Analytical Excellence through Industry Collaboration (AEIC) nutrient composition subcommittee which shares methodologies with other agricultural biotechnology companies and CRO representatives.

         Establish and implement GLP and non-GLP protocols for nutrient composition studies.

DuPont Pioneer, Wilmington, DE, 2005 to 2015

Research Scientist - Biochemical Analysis, Regulatory Science

         Contributed talents in analytical biochemistry, plant biochemistry, and plant physiology to spearhead nutrient composition analyses of transgenic crops as part of safety assessment of new products required for regulatory submissions.

         Governed GLP composition analyses performed by CROs and directed Biochemical Analysis group in developing analytical assays for non-routine GLP studies to support regulatory submissions.

         Created and implemented GLP and non-GLP protocols for nutrient composition studies.

         Performed and supervised extraction and quantification of acetylated amino acids, free amino acids, and triacylglycerides.

         Winner of 2012 Research Contribution Award, 2010 Biotech Achievement Award, and 2010 Regulatory and Biotech Affairs Award.

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DuPont Crop Genetics, Wilmington, DE, 2001 to 2005

Senior Research Biologist

         Led analytical biochemistry of soybean flavor including orchestrating analytical assays to identify plants with desired chemical phenotypes in support of metabolic engineering of crop plants.

         Planned, coordinated, and executed comprehensive biochemical experiments to aid in gene discovery.

         Extracted and quantified compounds from plant materials, soy protein isolate, and microorganisms.

         Purified and characterized putative flavor molecules, and meticulously documented findings.

         Extracted and quantified saponins, isoflavones, flavonols, lutein, lipids, phytosterols, phenolic acids, condensed tannins, and glyceollins.

         Effectively identified plant genes by production of target molecules in microorganisms.

DuPont Agricultural Products, Wilmington, DE, 1999 to 2001

Senior Research Biologist

         Investigated and defined biochemical pathways associated with biosynthesis of antifungal phytochemicals, systematically performed extraction and quantification of beta-amyrin and related saponins, and cloned candidate cDNAs and PCR products into yeast expression vectors.

         Conducted biochemical classification of oat saponin mutants and critically analyzed wheat EST microarray for candidate defense genes.

DuPont Agricultural Products, Newark, DE, 1992 to 1999

Research Biologist, Section Research Biologist and Senior Research Biologist

         Identified site of action of experimental herbicides, performed in vitro herbicide target and fungicide target assay development, methodically conducted in vitro chemical screening, and isolated corn chloroplasts and mitochondria from rat liver and avocado.

         Proactively formulated biochemical assays to screen chemical inhibitors, classify chemical structure/activity, and determine IC50 ratios.

Ph.D., Plant Physiology, Emphasis in Biochemistry, University of California, Davis, CA

M.S., Agronomy, Emphasis in Plant Physiology, University of Minnesota, St. Paul, MN

B.S., Agronomy, Emphasis in Chemistry, Washington State University, Pullman, WA

UV/Vis spectroscopy, HPLC with photodiode array detector, HPLC/Tandem mass spectrometry, GC/FID, GC/MS, HPLC-fluorescence detector, non-radioactive DNA sequencing, 35S DNA sequencing, high-speed and ultra-speed centrifuge, high- throughput chemical screening, spectrofluorometer, fluorescent and UV/Vis plate readers, reverse/normal/preparative HPLC, spectrophotometer

Phytochemical Society of North America

American Chemical Society

American Society of Plant Biologists

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1.    Breeze ML, Leyva-Guerrero E, Yeaman GR, Dudin Y, Akel R, Brune P, Claussen F, Dharmasri C, Golbach J, Guo R, Maxwell C, Privalle L, Rogers H, Liu K, Shan G, Yarnall M, Theide D, Gillikin N (2015)Validation of a method for quantitation of soybean lectin in commercial varieties. J Am Chem Soc 92:1085-1092

2.    Cong B, Maxwell C, Luck S, Vespestad D, Richard K, Mickelson J, Zhong C (2015) Genotypic and environmental impact on natural variation of nutrient composition in 50 non genetically modified commercial maize hybrids in North America. J Agric Food Chem 63:5321-5334

3.    Hong B, Fisher TL, Sult TS, Maxwell CA, Mickelson JA, Kishino H, Locke MEH (2014) Model-based tolerance intervals derived from cumulative historical composition data: Application for substantial equivalence assessment of a genetically modified crop. J Agric Food Chem 62:9916-9926

4.    Brink K, Chui C-F, Cressman RF, Garcia P, Henderson N, Hong B, Maxwell CA, Meyer K, Mickelson J, Stecca KL, Tyree CW, Weber N, Zeng W, Zhong CX (2014) Molecular characterization, compositional analysis, and germination evaluation of a high-oleic soybean generated by the suppression of FAD2-1 expression. Crop Sci 54:2160-2174

5.    Zeng W, Hazebroek J, Beatty M, Hayes K, Ponte C, Maxwell C, Zhong CX (2014) Analytical method evaluation and discovery of variation within maize varieties in the context of food safety: Transcript profiling and metabolomics. J Agric Food Chem 62:2997-3009

6.    Alba R, Phillips A, Mackie S, Gillikin N, Maxwell C, Brune P, Ridley W, Fitzpatrick J, Levine M, Harris S (2010) Improvements to the International Life Sciences Institute Crop Composition Database. J Food Compos Anal 23:741-748

7.    Hession AO, Esrey EG, Croes RA, Maxwell CA (2009) Correction to N-Acetylglutamate and N Acetylaspartate in soybeans (Glycine max L.), maize (Zea mays L.), and other foodstuffs [J Agric Food Chem 2008, 56, 9121. DOI: 10.1021/jf801523c]. J Agric Food Chem 57:9856

8.    Hession AO, Esrey EG, Croes RA, Maxwell CA (2008) N-Acetylglutamate and N-Acetylaspartate in soybeans (Glycine max L.), maize (Zea mays L.), and other foodstuffs. J Agric Food Chem 56:9121-9126

9.    Delaney B., Shen A-Z, Powley CR, Gannon S, Munley SA, Maxwell C, Barnett JF (2008) Acute and repeated dose oral toxicity of N-acetyl-L-aspartic acid in Sprague-Dawley rats. Food Chem Tox 46:2023-2034

10.  Maxwell CA, Restrepo-Hartwig MA, Hession AO, McGonigle B (2004) Metabolic engineering of soybean for improved flavor and health benefits. In J. Romeo, ed, Secondary Metabolism in Model Systems: Recent Advances in Phytochemistry. Elsevier, London 38:153-176

11.  Oi X, Bakht S, Leggett M, Maxwell C, Melton R, Osbourn A (2004) A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants. Proceedings National Academy of Sciences USA 101:8233-8238

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Addendum Page 2 of 2

12.  Yu O, Shi J, Hession AO, Maxwell CA, McGonigle B, Odell JT (2003) Metabolic engineering to increase isoflavone biosynthesis in soybean seed. Phytochemistry 63:753- 763

13.  Bartley GE, Maxwell CA, Wittenbach VA, Scolnik PA (1997) Cloning of an Arabidopsis thaliana cDNA for p-hydroxyphenylpyruvate dioxygenase (accession No. U89267) (PGR 97-065). Plant Physiol 113:1463

14.  Saari LL, Maxwell CA (1997) Target-site resistance for acetolactate synthase inhibitor herbicides. In R. De Prado, J. Jorr n and L. Garc a-Torres, eds, Weed and Crop Resistance to Herbicides. Kluwer Academic Publishers, Dordrecht, pp 81-88

15.  Dixon RA, Maxwell CA, Ni W, Oommen A, Paiva NL (1994) Genetic manipulation of lignin and phenylpropanoid compounds involved in interactions with microorganisms. In B.E. Ellis, G.W. Kuroki and H.A. Stafford, eds, Genetic Engineering of Plant Secondary Metabolism. Plenum Press, New York, pp 153-178

Patent Publications

1.     McGonigle, Brian; Maxwell, Carl A.; Hession, Aideen, Oonagh (Issued 2010 07 06) Compositions with increased phytosterol levels obtained from plants with decreased triterpene saponin levels. US7750210

2.     Caimi, Perry G.; Famodu, Omolayo O.; Lee, Jian-Ming; Miao, Guo-Hua; Maxwell, Carl A. (Published 2007 11 08) Disease resistance factors. US2007026135A1

3.     Bryan, Gregory T.; McGonigle, Brian; Maxwell, Carl A. (Issued 2006 11 14) Enzymes involved in triterpene synthesis. US7135624B2

4.     Falco, Saverio Carl; McGonigle, Brian; Maxwell, Carl A. (Published 2006 01 05) Transgenic soybean seeds having reduced activity of lipoxygenase. US2006005276A1

5.     McGonigle, Brian; Maxwell, Carl A.; Hession, Aideen O. (Published 2005 09 08) Method of improving soybean protein color by reducing levels of flavonol. US20050198710A1

6.     Allen, Stephen M.; Maxwell, Carl A.; Falco, Saverio Carl (Issued 2004 11 23) Genes encoding sulfate assimilation proteins. US6821764B2

7.     McGonigle, Brian; Maxwell, Carl A.; Hession, Aideen O. (Published 2004 01 15) Transgenic plants with a suppressed triterpene level. US0000 xxxxxx xxxx , xxxx , xxxxx 000008A1

8.     Butler, Karlene H.; Famodu, Omolayo O.; Maxwell, Carl A. (Issued 2003 05 27) Magnesium chelatase. US6570063B1

9.     Falco, Saverio Carl; Allen, Stephen M.; Maxwell, Carl A. (Issued 2003 04 15) Genes encoding sulfate assimilation proteins. US6548280B1

10.  Bryan, Gregory T.; McGonigle, Brian; Maxwell, Carl A.; Potter, Susan M.; Hwang, Der-Chyan (Published 2003 11 06) Enzymes involved in triterpene synthesis. US0000 xxxxxx xxxx , xxxx , xxxxx 000001A1

11.  Maxwell, Carl Arthur; Scolnik, Pablo Ariel; Wittenbach, Vernon Arie; Gutteridge, Steven (Published 2003 04 03) Plant gene for p-hydroxyphenylpyruvate dioxygenase. US0000 xxxxxx xxxx , xxxx , xxxxx 000002A1

12.  Hitz, William D.; Maxwell, Carl A.; Tao, Yong (Issued 2002 11 19) Polynucleotides encoding indole-3-glycerol phosphate synthase from soybean. US6482631B1